Welcome to the Kaganovich Lab website! We are an interdisciplinary group interested in super-resolution live-cell imaging, molecular neuroscience, protein folding and aggregation, genetics, and bioengineering
A bit about our research
Cells avoid the existential threat posed to their viability by the aggregation of non-native proteins by identifying misfolded proteins, degrading or refolding them, or directing their sequestration in protective inclusions.
We study how protein folding quality control and aggregation quality control are regulated in the cell over space and time. To put it slightly differently, we believe that protein folding quality control and aggregation quality control are regulated by controlling the sub-cellular distribution of specific quality control components at different times during the life of an organism or a cell and at stressful conditions.
The overall goal of our lab is to develop a full mechanistic understanding of neurodegenerative disease (including Huntington's, Alzheimer's, Parkinson's, and Lou Gehrig's Diseases), following the causative chain from the fundamental biology of intracellular quality control all the way up to the selective lethality of proteotoxic stress at the level of neural networks.
Our work is aimed at relating what we know about protein folding quality control and aggregation quality control at the biochemical level to the cell biological and physiological phenomena of inclusion formation that we observe in neurodegenerative diseases. To this end we apply a diverse set of tools from biochemistry, to yeast genetics, mammalian cell biology, drug screens, and simple model organisms.
Kaganovich Lab news!!!
Welcome diSPIM Selective Plane Illumination Microscope
We are the first lab in Israel to install a SPIM imaging system. This microscope uses 4 simultaneous laser sheets to rapidly image cells and C. elegans in 3D. The advantage of the SPIM system is speed (sub-second 3D stack of 40-100micron volume) and low to non-existent phototoxicity.
Dan will be speaking at:
December 22 - Technion Faculty of Medicine
January 14 - Tel Aviv University Department of Neurobiology
January 25 - University of Copenhagen, Denmark
February 8 - Harvard Medical School, Boston
February 11 - UPenn
September 12, 2016 - Protein Misfolding Jaques Monod Conference, Brittany, France
Story on our recent paper published jointly with the Schuldiner lab in Developmental Cell.
Congratulations to Ayelet-chen Abraham and Triana Amen who are both co-first authors together with Kelly Brock from the England lab on a paper that was just accepted to Structure!! This was a many year collaboration with the England lab which resulted in an exciting paper which will be posted online soon.
Congratulations also to Triana Amen whose collaboration paper with Ofer Moldavski from Maya Schuldiner's lab was just accepted in Developmental Cell.
The 2015 prizes for Kaganovich lab members are rolling in!
Congratulations to Triana Amen - Triana received First Place in the Best Poster competition at the EMBO conference on the regulation of aging and proteostasis
Triana also received First Place in the Poster competition for the entire faculty (Life Sciences, Physics, and Mathematics) at Hebrew University
Congratulations to Rivkah Brown - Rivkah received the Eckstein prize for her Masters research, which included a cash prize and an honorary lecture at the institute
Registration for our EMBO Workshop is now open!!!
We are organizing an EMBO workshop on Macromolecular assemblies at the crossroads of stress and function May 31-June4, 2015 in Jerusalem. Details and speaker list will be published soon.
Our paper: Dynamic JUNQ inclusion bodies are asymmetrically inherited in mammalian cell lines through the asymmetric partitioning of vimentin was just accepted for publication in PNAS and is now online.
Congratulations to Miko, Hanna, and everyone who worked so hard on the story!!
Dan's interview with BioAbroad - the Forum for Israeli Scientists Abroad
Coverage of the HUJI Quantitative Biology International Program in Inside Indiana University
Dan will be one of the speakers at the EMBO workshop on Aging and Proteostasis February 15-20. This is a great opportunity to sign up for the meeting and submit abstracts. There are special discounts for locals and for abstract presenters!
Hope to see you there and please get in touch if you're in town and would like to visit the lab!
International Students!!! Want to visit Hebrew U. for a summer/semester/year?
Get in touch with us through the international Quantitative Biology program.
We offer intense mini-courses taught by leading scientists from Israel and the US, semester-long or full year post-graduation research programs, exchange programs with courses that will count towards your college degree and more!
E R C!!!!!
The Kaganovich lab was recently awarded the prestigious ERC Starting Grant by the European Research Council.
We are looking for outstanding applicants to help us with this and other exciting projects! Here's a link to the Positions Open flyer.
The Kaganovich lab has started roasting coffee beans "in-house." So far this has been very successful. Colleagues and students are encouraged to visit and see for themselves.
We are always looking for new excellent students for PhD and MA. If you're interested, send Dan and email. You may also be interested in the new Advanced MA program at the Life Sciences Institute at HUJI and the Quantitative Biology program.
Check out our dancing neuron below. For more info about 4D imaging go to our Imaging page
We are looking for an excellent PhD and Masters students. Please get in touch with me if you're interested or just drop by and take a look at the lab!
Welcome to our Lab Homepage! We are located in the:
Department of Cell and Developmental Biology
Institute of Life Sciences
Hebrew University of Jerusalem
Edmond J. Safra Campus, Givat Ram, Jerusalem, Israel (map).
We are always interested in outstanding, self-motivated, and independent-minded students. If you're interested in applying for a position in the lab, please send me an email at firstname.lastname@example.org.
In your email please describe what made you interested in our lab and what you think you'd like to contribute to our research.
A note to applicants
Students looking to join the lab should send me an email detailing their past research experience, their goals and motivation for wanting to join the lab, and a couple of paragraphs describing what they would like to work on. Prospective students are also welcome to come by the lab, meet the lab members, and see if it is a good fit.
Students looking for a postdoctoral position should email a brief research proposal (similar to one you would write for a post-doctoral fellowship) describing an independent research direction that is broadly related to the interests of the lab, but also establishes a novel line of inquiry in the field. Although we will have plenty of opportunities to discuss research projects and specific experiments, the proposal is meant to demonstrate fluency in relevant research topics and ability to think and function independently, as is expected of a postdoctoral scientist. Please include one or two letters of recommendation with your CV and application.