Welcome to the Kaganovich Lab website! We are an interdisciplinary group interested in super-resolution live-cell imaging, molecular neuroscience, neuronal metabolism, and Neurodegenerative Diseases
A bit about our research
The focus of our group is on the mechanisms of cellular adaptations to stress and aging, in particular those involving dynamic sweeping rearrangements in cellular architecture and metabolic infrastructure. One prominent example of this type of stress response feature is a stress-induced change in affinities between proteins, often manifesting as protein aggregation and condensation.
The tendency of proteins to form aggregates and condensates has both an adaptive as well as a dysfunctional side. We study how protein folding quality control and aggregation quality control are regulated in the cell over space and time. We are also interested in understanding the adaptive function of membraneless organelles, such as Stress Granules.
The overall goal of our lab is to develop a full mechanistic understanding of neurodegenerative disease (including ALS or Lou Gehrig's Diseases), following the causative chain from the fundamental biology of Stress Granule dysfunction, all the way up to the selective lethality of proteotoxic stress at the level of neural networks.
To this end we apply a diverse set of tools from biochemistry, to yeast genetics, mammalian cell biology, drug screens, and simple model organisms.
Kaganovich Lab news
Congratulations to Triana Amen for her Cover Article, in Science Signaling.
This is Triana's third cover (she only needs one more...).